Bioorthogonal Reactions in Radionuclide Conjugates

Bioorthogonal reactions are a series of chemical reactions that occur in biological environments with high yields, selectivity, efficiency, and no side reactions. These reactions include copper-catalyzed alkyne-azide cycloaddition (CuAAC), strain-promoted alkyne-azide cycloaddition, inverse electron demand Diels-Alder (IEDDA) reaction, and more. These bioorthogonal reactions find extensive applications in various fields, including radionuclide conjugate, metabolic engineering, drug […]

Advances in Non-Viral Vector Delivery Systems for Nucleic Acid Drugs

Nucleic acid drugs are mainly divided into two major categories: small nucleic acid drugs and mRNA. Small nucleic acid drugs, also known as oligonucleotide drugs, include antisense nucleotides (ASO), small interfering RNA (siRNA), microRNA, nucleic acid aptamers, and others. mRNA products can be further categorized into mRNA vaccines and mRNA drugs. Characteristics of Nucleic Acid Drugs […]

Strain Improvement in Yeast

Yeast is a single-celled and versatile microorganism that is widely used in various industries, such as brewing, food, and biotechnology. However, not all yeast strains possess the desired characteristics required for optimal production. Therefore, methods of yeast strain improvement have been developed to enhance the desirable traits of yeast strains and to benefit industries involving […]