ADCP Assay

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Therapeutic antibodies have a number of essential mechanisms of action (MOAs), one of which is antibody-dependent cell-mediated phagocytosis (ADCP). Monocytes, macrophages, neutrophils, and dendritic cells can all mediate ADCP in vivo via FcyRIIa, FcyRI, and FcyRIIIa. According to its method, antibodies attach their homologous antigens to their target cells via their antigen recognition domains, and then use their Fc regions to attract phagocytes to the targets. Target cells are absorbed and broken down by phagocytes after becoming attached to their Fc receptors. Additionally, as a result of this process, the effector cells create soluble molecules that support and fuel the immune response. In the creation of therapeutic antibodies, especially for biosimilars, ADCP function is crucial.

 

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