Depending on the subcellular target of change, we have devised a number of techniques for introducing tiny compounds through the outer membrane of living bacteria. Depending on the requirements of your particular project, we can insert small molecules into the surface glycans (lipopolysaccharide, proteoglycans), surface proteins, surface lipids, peptidoglycan, or lipid membranes.
Conjugates
Our platform enables a wide range of substances, including nucleic acids, lipids, carbohydrates, fluorophores, affinity tags, spectroscopic probes, crosslinking agents, cytotoxic medicines, vaccine adjuvants, antibiotics, etc. to modify the surfaces of bacteria.
Applications
Studies on host-pathogen interactions, directed evolution, molecular imaging, proteomic and glycomic analyses, immunotherapy, and clinical diagnostics have all made use of bacteria surface engineering.